Pembrolizumab induced hypophysitis
WebJul 28, 2024 · The number of immune-related endocrine dysfunctions (irEDs) has concurrently increased with the widespread use of immunotherapy in clinical practice and further expansion of the approved indications for immune checkpoint inhibitor (ICI) in cancer management. A retrospective analysis was conducted on consecutive patients ≥18 years … WebJan 6, 2024 · The mechanism responsible for the development of ACTH deficiency associated with pembrolizumab remains to be fully elucidated, but hypophysitis is a possible etiology in the present case. Lymphocytic hypophysitis, the most common form …
Pembrolizumab induced hypophysitis
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WebJun 5, 2024 · Hypophysitis was initially considered an irAE specific to ipilimumab, likely due to the high expression of CTLA-4 antigens in the pituitary . Anti-CTLA-4 antibodies can cause autoimmune hypophysitis in up to 10% of patients. However, anti-PD-1 antibody-induced … WebImmune checkpoint inhibitor–induced hypophysitis is a rare complication of pembrolizumab, but the effects of drug‐induced hypophysitis on pre‐existing pituitary lesions are unknown. The authors treated an unusual case of pembrolizumab‐induced hypophysitis that resulted in acute exacerbation of a pre‐existing pituitary cystic lesion ...
WebDec 17, 2024 · Notably, the incidence of hypophysitis is higher with use of anti-CTLA-4 inhibitors, such as ipilimumab (0–17%), than with PD-1 inhibitors nivolumab and pembrolizumab (0.5–2.0%), 26 whereas PD-L1 inhibitors rarely cause hypophysitis. 37,38 The incidence is increased with higher ipilimumab doses, and older age and male gender … WebThyroid abnormalities and hypophysitis are the two most common endocrine irAEs, although primary adrenal insufficiency and type 1 diabetes mellitus have also been reported. The endocrine clinic recently reviewed thyroid abnormalities among patients with cancer …
WebImmune checkpoint inhibitor–induced hypophysitis is a rare complication of pembrolizumab, but the effects of drug-induced hypophysitis on preexisting pituitary lesions are unknown. The authors treated an unusual case of pembrolizumab-induced hypophysitis that resulted in acute exacerbation of a preexisting pituitary cystic lesion causing ... WebAug 31, 2024 · He was started on pembrolizumab immunotherapy about 9 months before presentation which he tolerated well. Subsequent endocrine work ups revealed features consistent with hypophysitis that lead...
WebAug 7, 2024 · We report a case of single-agent pembrolizumab-induced hypophysitis characterized by early disease onset after anti-PD-1 treatment initiation, panhypopituitarism and increased pituitary mass. These are distinct features compared to the majority of …
WebJan 21, 2024 · In a study of ipilimumab-induced hypophysitis, 80% had central adrenal insufficiency. Lu et. al. found hypophysitis occurred in 3.25% of patients using ICIs. Of these, it was more common with combination … how to do steam gift cardsWebMay 9, 2024 · The cause of hypothyroidism in patients 8, 9, and 10 before initiation of pembrolizumab were ipilimumab-induced, interferon-induced, and primary hypothyroidism, respectively. There was no sex predilection for thyroid-related irAEs ( P = 0.56). how to do steam game shareWebCPI-T1DM is determined as a severe insulin deficiency clinical manifestation of ketoacidosis and low or absence of C-peptide level. 2. Pembrolizumab-induced diabetes is rare, a small number of cases initially presented with life-threatening diabetic ketoacidosis if not diagnosed timely and handled properly. Here we describe a serious case of ... lease nancylease netherlandsWebJun 17, 2024 · Hypophysitis is quite rare following treatment with PD-1 antibodies (0.5%) but is more common with ipilimumab (13.6%). 6 Hypophysitis with PD-1 blockade is usually diagnosed later, at a median of 25.8 weeks, compared with ipilimumab at 9.3 weeks or 12.5 weeks for the patients receiving combination therapy. 7,8 Headache and pituitary … how to do steak in air fryerWebJul 15, 2024 · Faje A, Reynolds K, Zubiri L, Hypophysitis secondary to nivolumab and pembrolizumab is a clinical entity distinct from ipilimumab-associated hypophysitis: Eur J Endocrinol, 2024; 181; 211-19 3.. Sonehara K, Tateishi K, Hirabayashi T, A case of lung adenocarcinoma with long-term response after late-onset pembrolizumab-induced acute … lease n buy with easeWebJun 5, 2024 · Pembrolizumab is an immune checkpoint inhibitor that targets the programmed cell death protein 1 antigen to stimulate an immune response against tumor cells. It has successfully induced remission in patients with severe metastatic disease, including those refractory to other chemotherapeutic regimens. lease networks transparency in coverage