Klf5 is required

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August undefined, 2024

WebFeb 21, 2024 · Here we report that, in human and mouse prostates, Klf5 is expressed in both basal and luminal cells, with basal cells preferentially expressing acetylated Klf5. Functionally, Klf5 is... WebMar 30, 2024 · Studies in many cell lines have shown that KLF5 is an important growth promoting and differentiation inhibitory gene (Rane et al., 2024 ). Recently, some researches have reported that KLF5 plays a key role in the regulation of angiogenesis ( Ci et al., 2015 ), but whether it regulates angiogenesis in liver fibrosis has not been explored.

A stem cell marker KLF5 regulates - Nature

WebAbstract Krüppel-like factor 5 (KLF5) is a member of the KLF family. Recent studies have suggested that KLF5 regulates the expression of a large number of new target genes and … WebMar 17, 2024 · Acetylation of KLF5 is required for TGF-β to induce EMT. TGF-β is a master regulator of EMT 45, a process believed to promote tumor metastasis 25. We thus tested whether acetylation of KLF5 is involved in EMT. testiranje na covid novi sad cena

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WebAbstract Krüpple-like factor 5 (KLF5) is required for the development of the embryo and multiple organs, such as the lung and intestine. KLF5 plays a pro-proliferative and … WebSep 3, 2024 · Crucially, when the cell growth genes regulated by KLF5 are activated, patients have lower survival rates. Further work is now required to examine whether this finding could help to identify patients who are most at risk from developing cancer. WebDec 15, 2024 · These data support that KLF5 is required for ADM and oncogenic KRAS-induced PanIN formation. Ndrg2 is a gene of interest detected by the RNA sequencing and validated by qRT-PCR and Western blot, and it is up-regulated in the Klf5-deleted mice 2 days after cerulein-induced pancreatitis . NDRG2 is a member of a family of alpha/beta … testiranje na covid lokacije

Klf5 is involved in self-renewal of mouse embryonic stem …

Klf5 acetylation regulates luminal differentiation of basal ... - Nature

WebAug 15, 2008 · Our results demonstrate that Klf5 is an essential factor of the core regulatory network that maintains ESCs in the undifferentiated state. Klf5 KD does not modify levels of Klf2 and Klf4, thus suggesting that the presence of these two factors cannot completely substitute for the reduction or absence of Klf5. WebOct 27, 2024 · The KLF5 protein participated in the core-regulatory circuitry together with co-factors (BRD4, MED1, and RAD21), which constructs the three-dimensional genome … batman keaton suitWebJun 11, 2024 · We conclude that Klf5 is required for the normal function of the hepatobiliary system and that the K5-Cre; Klf5fl/fl mouse is an excellent model to probe the molecular events interlinking damage and regenerative response in the liver. Introduction batman keaton stl 3d

"WebOct 1, 2011 · In the present study, we demonstrate that KLF5 is required for normal maturation of the murine bladder urothelium and suggest that Grhl3 and Pparγ are candidate transcriptional downstream targets that mediate this process. Deletion of Klf5 from the developing bladder urothelium causes prenatal VUR, hydroureter, and hydronephrosis. Go … " - Klf5 is required

Klf5 is required

(PDF) Kruppel-like factor 5 is required for perinatal lung ...

WebKLF5 is a DNA-binding transcriptional regulator, and contains three independent C 2 H 2 zinc fingers. 11 KLF5 is expressed in multiple human tissues including small intestine, colon, … WebKLF5 is a basic transcription factor necessary for cell proliferation in epithelial homeostasis. For example, it is highly expressed in proliferating epithelial cells including immortal but untransformed epithelial cell lines as well as proliferating primary cultures of epithelial cells, which mostly represent progenitor cells ( 18 , 19 , 20 ).

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WebJan 5, 2024 · Androgen deprivation resistance is the final common step of many advanced prostate cancers. Li et al. identified the key promoting role of KLF5, the transcription factor Krüppel-like factor 5, in the androgen-AR signaling of LNCaP and C4-2B prostate cell lines. The authors considered this effect as a potential target to develop new therapeutic ... WebApr 4, 2024 · Functionally, Klf5 is indispensable for maintaining basal progenitors, their luminal differentiation, and the proliferation of their basal and luminal progenies. A novel …

WebAug 12, 2024 · Abstract Krüpple-like factor 5 (KLF5) is required for the development of the embryo and multiple organs, such as the lung and intestine. KLF5 plays a pro-proliferative … WebMar 17, 2024 · These findings indicate that while KLF5 is indispensable for tumor formation, acetylation renders KLF5 less potent in tumor growth but able to maintain a mesenchymal …

WebJul 29, 2014 · Rapid replacement of Klf5-mutant crypts with wildtype cells and reduction of stem cell markers suggests further that Klf5 is required for self renewal of intestinal stem cells. Discover the world ... WebKrüpple-like factor 5 (KLF5) is required for the development of the embryo and multiple organs, such as the lung and intestine. KLF5 plays a pro-proliferative and oncogenic role in several carcinomas, including breast cancer.

WebOct 1, 2011 · KLF5 is required for stratification and terminal differentiation of urothelial cells. Defects in urothelial maturation induces hydronephrosis. KLF5 is not required for maturation of the bladder neck and urethral epithelium. Grhl3 and Pparγ are candidate targets of …

WebLiberti et al. show that Klf5 is required to maintain alveolar epithelial type 1 (AT1) versus type 2 (AT2) cell fate during murine lung development. Furthermore, they demonstrate that Klf5 represses adult AT2 cell responsiveness to inflammatory signaling to inhibit proliferation and promote differentiation during lung regeneration after acute injury. testiranje na covid novi sad pcrWebKrüppel-like factor 5 (KLF5) is a zinc-finger transcription factor known to play a pivotal role in the pathogenesis of cardiovascular disease. Here, we show that neonatal heterozygous KLF5 knockout mice exhibit a marked deficiency in white adipose tissue development, suggesting that KLF5 is also required for adipogenesis. testiranje na covid osijek drive inWebFeb 21, 2024 · We thus propose that acetylation of Klf5 is required for a prostate to maintain a pool of basal progenitors and a balanced proliferation and differentiation of such cells. Without Klf5 acetylation, excess basal cells unnecessarily differentiate into luminal cells, which exhausts the pool of basal progenitor cells, causes excess luminal cells ... batman keaton flashWebHere, we show that the Klf5-deficient embryos fail to implant due to defective trophectoderm development.We also show that Klf5 is required for the derivation of ESCs from ICM cells. Interestingly, Klf5-deficient ESCs can be established by knocking out both Klf5 alleles in mouse ESCs. The Klf5 knockout (KO) ESCs can maintain pluripotency but show increased … batman keaton castWebApr 11, 2024 · SPI1, HIF1A, STAT1, KLF5, RUNX1, MBD1, SP1, and WT1 may be involved in the regulatory mechanisms of DN development. Our study may provide a potential biomarker or therapeutic locus for the study of DN. ... involved in the progression of DN is required to explore more DN-related biomarkers and improve their relevant clinical evidence, thus ... testiranje na covid osijekWebSep 15, 2015 · Klf5 is required for the expression of Cdx2 in TE cells, while it activates pluripotency gene expression in ESCs. How the transcriptional activity and downstream targets of Klf5 is regulated in these two distinct cell types, remains elusive. testiranje na covid novi sad privatnoWebDec 10, 2013 · KLF5 was originally cloned as the Basic transcription element binding protein 2 (BTEB2) gene 4. Prior to the reclassification of KLF family nomenclature KLF5 was known as Intestinal krüppel-like factor ... Treatment with a PPARδ agonist is required for deSUMOylation of KLF5 and subsequent activation of these genes. batman keaton wallpaper