Irf3 knockout mice
WebGEO help: Mouse over screen elements for information. Scope: Format: Amount: GEO accession: Series GSE209654: Query DataSets for GSE209654: Status: Public on Apr 14, … WebKnockout validated Reacts with: Mouse, Human Related conjugates and formulations Carrier Free HRP PE You may also be interested in Anti-IRF3 (phospho S386) antibody [EPR2346] - BSA and Azide free (ab182859) Knockout Human IRF3 knockout HeLa cell line (ab255345) Knockout Human IRF3 knockout A549 cell line (ab267097) View more associated products
Irf3 knockout mice
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WebAged WT and IRF3-KO mice were subject to CLP to induce sepsis, and a second group of aged WT mice were subject to sham surgery as a control. Graphs show pooled male and … WebMay 21, 2024 · To investigate the role of IRF7 in adipocytes, we examined gene expression patterns in 3T3-L1 cells infected with a retrovirus carrying the IRF7 gene and found that enforced IRF7 expression induced the expression of monocyte chemoattractant protein-1 (MCP-1), a key initial adipokine in the chronic inflammation of obesity.
WebAdditionally, TAT-PAMAM/pBud-H5-GFP-IRF3 vaccination increased the level of IL-2, IL-15, IL-12, IL-6, and TNF-α cytokines, which are also able to enhance the IFN-γ production. Studies conducted in IL-12 knockout mice have shown that IL-12 is essential in enhancing IFN-γ gene expression following endotoxin administration. WebThe IRF3 conditional knockout mouse may be a useful tool to identify cell type-specific functions of this transcription factor. Abstract IFN regulatory factor 3 (IRF3) is a …
WebBackground: Malignant pleural mesothelioma (MESO) has a poor prognosis despite aggressive treatment with surgery, radiation and chemotherapy, and novel therapeutic approaches are needed. IRF3 is a downstream molecule of the cGAS/STING signaling pathway, but its roles have not been investigated in MESO. Methods: Various murine … WebSep 23, 2010 · We show in knockout mice that Irf3 deficiency causes severe tissue pathology and that effector functions controlled by IFNβ are involved. Finally, in highly disease-prone pyelonephritis patients we found a high frequency of IRF3 promoter polymorphism compared to asymptomatic bacterial carriers or controls.
WebSee Taconic Bioscience’s Constitutive Knock Out mouse, model # Gpr183. Toggle navigation. ... For most lines, the mouse ES cells used in generating the model are of the …
WebJan 15, 2024 · IFN regulatory factor 3 (IRF3) is a transcription factor that is activated by multiple pattern-recognition receptors. We demonstrated previously that IRF3 plays a … fishtailing carWebApr 11, 2024 · Far1 KO mice were subviable and displayed growth retardation. The adult KO male mice had smaller testes and were infertile. H&E and immunofluorescent staining … fish tailing meansWebTo address this, we utilize a knockout mouse model to investigate the effect of ILRUN on cytokine expression in splenocytes and on the development of immune cell populations in the spleen and thymus. We show elevated production of tumor necrosis factor and interleukin-6 cytokines in ILRUN-deficient splenocytes following stimulation with the ... fish tailing gloveWebJul 25, 2024 · To demonstrate the role of SIRT1 in regulating IRF3 LLPS and downstream innate antiviral immunity, we isolated mouse embryonic fibroblasts (MEFs) from Sirt1 KO (Sirt1 −/−) mice 30. fishtailing meaning carWebIRF-3(-/-) and select IRF-3/7(-/-) mice were resistant to LP-BM5-induced pathogenesis. However, further analyses strongly suggested that resistance could be attributed to strain … can drinking alcohol cause lung cancerWebNov 4, 2024 · Recent studies have suggested that STING signaling is necessary for the anticancer immune response based on the following observations: on the one hand, STING knockout mice and IRF3 knockout mice show impaired spontaneous T-cell responses against tumors [34, 35]; on the other hand, STING agonists show a favorable effect in … can drinking alcohol cause leg painWebNov 2, 2024 · To identify potential IRF3-associated lncRNAs in vivo, we first generated the genetic manipulated mice with a FLAG-tag sequence inserted at the 3′ end of the coding sequence of Irf3 genes (Irf3 flag/flag) to facilitate the purification of endogenous IRF3 protein.Then we performed FA-CLIP with anti-FLAG antibody in primary mouse peritoneal … can drinking alcohol cause stomach problems